About Us

Our laboratory studies the pathogenic bacterium Staphylococcus aureus. We are interested in determining how S. aureus adjusts from a lifestyle as a transient commensal to a virulent pathogen through metabolic adaptation and evasion of host immune defenses. We are currently investigating the mechanisms of action of several immunomodulatory factors produced by S. aureus that disrupt innate immunity and enhance pathogenesis. Our research uses elements of bacterial genetics, biochemistry, immunology, and cell biology to define how these factors modulate innate immunity in vitro and in vivo, ultimately allowing us to determine how S. aureus subverts innate immune defenses. In addition, we are investigating the effects of nutritional restriction within host tissues on S. aureus viability. In doing so, we aim to identify novel mechanisms used by S. aureus to adapt to life inside an infected host.